| NFL Fantasy Fifty |
| Rk | P | A | Player | Pos | TM | Comment |
| 1 | | | Larry Johnson | RB | KC | Super Bowl ring a higher priority than rushing for 2,000 yds |
| 2 | | | Shaun Alexander | RB | SEA | Seattle TD conditions: Always clear |
| 3 | | | L. Tomlinson | RB | SD | Fewer scores: Philip Rivers is no Drew Brees |
| 4 | | | Tiki Barber | RB | NYG | '05 total YD leader will add more TDs |
| 5 | | | Clinton Portis | RB | WAS | Given more TD chances after offensive upgrades |
| 6 | | | LaMont Jordan | RB | OAK | Mastering the Art of running |
| 7 | | | Steven Jackson | RB | STL | Breaks through to elite w/ Linehan |
| 8 | | | Rudi Johnson | RB | CIN | May have more value if C. Palmer misses time |
| 9 | | | Cadillac Williams | WR | TB | Will he avoid the shop for repairs? |
| 10 | | | Domanick Davis | RB | HOU | Hasn't really had a bad year in his NFL career in Houston |
| 11 | | | Edgerrin James | RB | ARI | Zona's '05 run blocking was historically awful |
| 12 | | | Ronnie Brown | RB | MIA | Is Nos. 1 and 2 options in run game w/o Williams |
| 13 | | | Steve Smith | WR | CAR | A duplication of '05 would be amazing |
| 14 | | | Willis McGahee | RB | BUF | Will missing team OTAs hurt? |
| 15 | | | Reuben Droughns | RB | CLE | Winslow looking good and may draw LBs away from the line |
| 16 | | | Marvin Harrison | WR | IND | Is still most reliable second rounder on the board |
| 17 | | | Terrell Owens | WR | DAL | Dancing with the Stars: Judging plenty of TD steps |
| 18 | | | Chad Johnson | WR | CIN | May become very frustrated very quickly if CIN starts slow |
| 19 | | | Anquan Boldin | WR | ARI | Beware of Warner's injury history |
| 20 | | | Larry Fitzgerald | WR | ARI | Will there be enough touches for 100 catches? |
| 21 | | | Torry Holt | WR | STL | Can Bulger stay healthy and produce in new system? |
| 22 | | | Randy Moss | WR | OAK | Will his fantasy production be as good as his smoothies? |
| 23 | | | Julius Jones | RB | DAL | Don't drop out early this season |
| 24 | | | Tatum Bell | RB | DEN | Ready to take mantle left by Terrell Davis, Clinton Portis |
| 25 | | | Santana Moss | WR | WAS | Was '05 a fluke? Elect Moss and Brunell for fantasy party |
| 26 | | | Reggie Wayne | WR | IND | Season like '04 more likely w/o James |
| 27 | | | Hines Ward | WR | PIT | Will Big Ben be the same after the accident? |
| 28 | | | Brian Westbrook | RB | PHI | Andy Reid wants to increase Westy's workload |
| 29 | | | Kevin Jones | RB | DET | No excuses this time with Martz on board |
| 30 | | | Warrick Dunn | RB | ATL | He's in for 1,000 yards, but likely robbed of TDs again |
| 31 | | | DeShaun Foster | RB | CAR | He'll produce 100-yard games until he's injured |
| 32 | | | Chris Chambers | WR | MIA | New QB will be an adjustment; Look for late surge |
| 33 | | | Plaxico Burress | WR | NYG | Cruising to more big games in 2nd Giants year |
| 34 | | | Joey Galloway | WR | TB | Now wily and fast, is a steal as second WR |
| 35 | | | Peyton Manning | QB | IND | Recently joked he may get involved in IND's running game |
| 36 | | | Antonio Gates | TE | SD | Still the team's leading receiving threat |
| 37 | | | Willie Parker | RB | PIT | Still questions on whether he'll be full-time RB |
| 38 | | | Reggie Bush | RB | NO | Looking to put off-the-field troubles behind him |
| 39 | | | Jeremy Shockey | TE | NYG | One of a few game-changing TEs in the game |
| 40 | | | Deion Branch | WR | NE | Who else will step up and catch Brady's passes? |
| 41 | | | Darrell Jackson | WR | SEA | The offense is returning almost completely in tact |
| 42 | | | Rod Smith | WR | DEN | Still Denver's No. 1 receiver |
| 43 | | | Roy Williams | WR | DET | Health is an issue, but Mike Martz will utilize him |
| 44 | | | Derrick Mason | WR | BAL | More likely to be a league leader in catches w/ McNair |
| 45 | | | Tom Brady | QB | NE | QB is more of a fifth round pick than a fourth |
| 46 | | | Matt Hasselbeck | QB | SEA | Find QB value with this fifth-round pick |
| 47 | | | Carson Palmer | QB | CIN | Wait until camp to see if he's truly healthy |
| 48 | | | Eli Manning | QB | NYG | Will be even better after first full year as starter |
| 49 | | | Chester Taylor | RB | MIN | Favorite to be the starter, but will he share? |
| 50 | | | Fred Taylor | RB | JAC | Ran well in camp and set to be featured back |